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Oral Infections and Alzheimer's Disease


Bacterial and viral infections commonly found in periodontal disease may impact the brain either directly or though systemic signals to the brain. This may contribute to the development of Alzheimer's disease. Further evidence is needed to determine whether pathogens contribute uniquely to Alzheimer's disease.

Also, periodontal infection may elevate the systemic inflammatory response and thus contribute to existing brain and vascular pathologies that would impact brain function. Periodontal disease and Alzheimer's disease may also share genetic traits related to production of inflammatory mediators.

Watts, A.; Crimmin, E.M.; Gatz.M.: Inflammation as a potential mediator for the association between periodontal disease and Alzheimer's disease. Neuropsychiatric Disease and Treatment. 4(5):865-876, 2008.

Periodontal pathogen Treponemas was detected using species specific PCR and antibodies. Importantly, co-infection with several spirochetes occurs in Alzheimer's Disease (AD). The analysis of reviewed data following Koch's and Hill's postulates shows a probable causal relationship between neurospirochetosis and AD. Spirochetal infection occurs years or decades before the manifestation of dementia. As adequate antibiotic and anti-inflammatory therapies are available, as in syphilis, one might prevent and eradicate dementia.

Miklossy: Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. Journal of Neuroinflammation 2011 8:90.





Next: Oral Infections and Life Expectancy





 

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